Heterocyclic Compounds

Synthesis of Some New Heterocyclic Compounds with Potential Biological Activity

A series of new 2-arylimino-3-aryl-5-[5?-(3,4-dichlorophenyl)-2?-furylidene]-4-thiazolidinones (3a-l) have been synthesised by the condensation of 5-(3,4-dichlorophenyl)-2-furaldehyde 1 with 2-arylimino-3-aryl-5H-4-thiazolidinones 2 in glacial acetic acid. The physical and spectral data of the synthesised compounds are determined. The synthesised compounds have been screened for their in vitro ...

Introduction of Medicinal Chemistry & Heterocyclic Compounds

Preparation and Reactions of Heterocyclic Compounds II

Commercial preparation of furan proceeds by way of the aldehyde, furfural, which in turn is generated from pentose containing raw materials like corncobs, as shown in the uppermost equation below. Similar preparations of pyrrole and thiophene are depicted in the second row equations. Equation 1 in the third row illustrates a general preparation of substituted furans, pyrroles and thiophenes fro...

Palladium-catalyzed benzylation of heterocyclic aromatic compounds.

Broadly applicable palladium-catalyzed heteroarene benzylation reactions are described with a focus on the most challenging heterocyclic classes under traditional benzylation techniques such as sulfur-containing heterocycles and those bearing functional groups that would be incompatible with reactions requiring Lewis acids and/or strong bases.

Transition metals catalyzed synthesis novel heterocyclic compounds

Based on my research experience and academic career, my research plan is to develop new synthetic reactions to create heterocyclic molecules having useful properties as functional materials or biological activities. Reactions I am going to study on can be classified into the following two categories. Project 1: Transition metal-catalyzed cascade cyclization and oxidative cross couplings reactio...